The Silent Frontier: Why Pregnancy and Fertility Sit at the Center of the Climate Crisis

Prof. Melissa Mezzari

Melissa Paola Mezzari, Ph.D.

Research and Project Lead - YON E Health

There’s something I want to gently place on the table. Not as a scientist presenting data, but as someone who has spent years studying systems and watching patterns emerge.

When we talk about climate change, we rarely talk about pregnancy. And yet pregnancy may be one of the most climate-sensitive states of human life.

That isn’t symbolic language. It’s physiology.

During pregnancy, the body performs one of its most complex adaptations. Blood volume rises dramatically. The immune system recalibrates so it can protect without rejecting. Hormones coordinate across organs with astonishing precision. Temperature regulation tightens. The margin for error narrows.

It is a state of heightened sensitivity. It is beautifully adaptive, but delicately balanced.

Now place that body inside a world that is getting hotter.

Heat and the Fragile Balance of Late Pregnancy

Researchers have been studying what happens under those conditions for years. The patterns are no longer subtle. Large population studies show higher rates of preterm birth, low birth weight, and stillbirth during periods of extreme heat. According to the United Nations Population Fund, even a 1°C increase in temperature in the week before delivery correlates with a measurable increase in stillbirth risk.

Those statistics can feel clinical; but they represent families, expectations, futures.

To understand why this happens, we have to return to physiology. Pregnancy increases internal heat production. At the same time, the body’s ability to dissipate heat becomes less efficient. Circulation is constantly negotiating between cooling the skin and nourishing the placenta. Under sustained high temperatures, that negotiation becomes strained. Blood flow shifts. Inflammatory pathways activate. Hormonal signals that normally cue labor at term can be nudged earlier than intended.

Nothing about this process is theatrical. It is incremental. Subtle. Biological.

But small shifts, repeated across populations, become measurable outcomes.

When we describe climate change as a “risk multiplier,” this is what that means at the level of the body.

Before Conception: Fertility Under Environmental Pressure

The story doesn’t begin in the third trimester. In many ways, it begins much earlier.

Fertility itself is exquisitely regulated through the hypothalamic–pituitary–gonadal axis,  a hormonal loop that depends on precision. Temperature matters. Chronic stress matters. Chemical exposure matters.

Climate-driven floods and storms redistribute endocrine-disrupting compounds such as BPA, phthalates, and PFAS into soil and water systems. These compounds accumulate quietly in the body. They do not announce their presence. They interfere.

Eggs and sperm develop within that chemical background. Cycles become irregular. Conception may take longer. Ovarian reserve can decline faster than expected.

When fertility challenges appear, we often turn inward: toward age, genetics, lifestyle. Environmental context rarely enters the conversation. Silence can subtly shift responsibility onto the individual body.

But bodies are not isolated systems. They are embedded within environmental ones.

If the environment shifts, reproduction feels it.

Across the Life Course: Cancer Risk and Menopause

Climate sensitivity does not end with pregnancy or fertility. It stretches across the female life course.

Recent multi-country research suggests that for every 1°C increase in temperature, prevalence and mortality rates for breast, ovarian, and cervical cancers rise. Heat may alter exposure pathways and cellular behavior in ways we are still working to fully understand.

Persistent organic pollutants have also been associated with earlier onset of menopause, in some cases several years earlier than anticipated. For women already in transition, higher ambient temperatures intensify hot flashes, disrupt sleep, and strain mental health.

What we are seeing is not a single effect. It is a shift in timing, duration, and lived experience.

The biological timeline itself begins to move.

Disease, Displacement, and the Invisible Load

Layered onto physiology are social realities.

As temperatures rise, mosquito-borne illnesses expand into new regions. Pregnant women are biologically more attractive to mosquitoes due to increased blood flow and carbon dioxide output. Malaria, dengue, Zika. These infections carry specific risks during pregnancy.

At the same time, women and girls represent a large proportion of those displaced by climate events. Displacement increases physical labor, reduces access to reproductive healthcare, and disrupts continuity of care in ways that are rarely visible in climate dashboards.

Care responsibilities do not pause during crisis. They intensify.

When water sources move farther away, someone walks farther. When clinics close, someone absorbs the delay. These burdens often settle on women’s bodies.

And yet reproductive health remains marginal in many national climate strategies. Analyses involving institutions such as Queen Mary University of London show that menstrual health and reproductive rights are seldom explicitly integrated into climate adaptation frameworks.

That absence may not be intentional. But it is structural.

Where Responsibility Quietly Falls

When reproductive health is not built into climate planning, responsibility shifts to individuals.

Stay cool. Avoid exposure. Be resilient.

But resilience without structural support is not resilience, it is expectation.

If pregnancy is among the most climate-sensitive physiological states, then adaptation planning must reflect that. Clinics must remain functional during disasters. Cooling infrastructure must be accessible to pregnant individuals. Health data should be disaggregated by sex, so patterns are not averaged away. Clinician training should integrate environmental exposure into reproductive counseling proactively.

This is not about elevating one issue above all others. It is about aligning systems with biology.

Listening to the Signals

Science now allows us to see patterns that were invisible only a decade ago. We can correlate temperature spikes with pregnancy outcomes. We can track pollutant exposure across life stages. We can measure what was once anecdotal.

The question is not whether the signals exist.

They do.

The question is whether we allow those signals to inform policy and planning.

Climate change is often framed in terms of infrastructure and emissions. Those matter deeply. But climate change is also lived in bodies: in hormonal cycles, in placental circulation, in menopausal transitions, in fertility journeys that unfold quietly and personally.

When we center women’s health in the climate conversation, we are not narrowing the lens.

We are sharpening it.

Pregnancy, fertility, menopause: these are not peripheral biological states. They are central to human continuity. They register environmental stress with remarkable clarity.

If we want to understand how fast our world is changing, we should pay attention to where the signals appear first.

They are already there.

We simply must be willing to listen.

At YON E Health, we trust in science and it is pointing all of us toward a different future of healthcare. One where treatment is shaped by our own biology rather than broad averages. Because if climate change is already shaping women’s health, choosing not to measure its effects is no longer neutral. It is, in itself, a decision.

References

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